Protein Details: Short transient receptor potential channel 4

Protein ID

ICDB_Pro_1659

Protein Name

Short transient receptor potential channel 4

Gene Name

TRPC4

Organism

Homo sapiens (Human)

Length

977 amino acids

AlphaFoldDB

AF-Q9UBN4-F1-model_v4.pdb

Function

Sequence

MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPREKQRKVNFVTDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Prostate Cancer and Optic Atrophy

Location

Strongly expressed in placenta. Expressed at lower levels in heart; pancreas; kidney and brain. Expressed in endothelial cells. Expressed in endothelial cells. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain. .

DOI ID

10.1042/bj3510735; 10.1016/s0014-5793(00)02362-0; 10.1074/jbc.m109850200; 10.1038/nature02379; 10.1101/gr.2596504; 10.1016/s0092-8674(00)81233-7; 10.1242/jcs.115.17.3497; 10.1073/pnas.102596199; 10.1161/01.res.0000193597.65217.00; 10.1074/jbc.m500391200; 10.1074/jbc.m503646200; 10.1016/j.ceca.2007.07.009; 10.1074/jbc.m709729200; 10.1074/jbc.m109.068304; 10.1074/jbc.m109.060301; 10.1126/science.1133427

RefSeq

NP_001129427.1 [Q9UBN4-2]; NP_001129428.1 [Q9UBN4-4]; NP_001129429.1 [Q9UBN4-3]; NP_001129430.1 [Q9UBN4-6]; NP_003297.1 [Q9UBN4-5]; NP_057263.1 [Q9UBN4-1];